Volumetric dosing to create a liquid solution from powder – RC Discount Shop

Volumetric dosing to create a liquid solution from powder

Published Aug 31, 2019

Volumetric dosing to create a liquid solution from powder | RC Discount Shop

How to create your own liquid solution from powder

This guide is provided for informational and educational purposes only. We do not encourage you to break the law and cannot claim any responsibility for your actions.

Volumetric dosing is the process of dissolving a compound in a liquid to make it easier to measure. In the interest of harm reduction, it is important to use volumetric dosing with certain compounds that are too potent to measure with traditional weighing scales. This technique makes it possible to use a cheap $30 scale and still measure accurately to a few milligrams.

Many psychoactive substances, including benzodiazepines and certain psychedelics, are active at less than a single milligram. Such small quantities cannot be accurately measured with common digital scales, so the drug must instead be dosed volumetrically by weighing out larger amounts of the compound and dissolving it in a calculated volume of a suitable liquid.

There is a volumetric dosing calculator located here which will determine the amount of the substance and solvent needed, as well as the concentration.

Materials needed

  • Solvents, such as alcohol (vodka or everclear work best), water, propylene glycol, or glycerine (depending on the substance)
    Note: Search the internet to determine what solvent to use. All substances should dissolve in alcohol, but many substances will not dissolve in water.
  • A liquid measurement device, such as a syringe (can be an oral syringe or one with a needle), graduated cylinder, eyedropper, measuring pipette, or measuring cups (teaspoon, tablespoon, etc.)
  • Milligram scale
  • Sealed storage bottle or container - Note: the solution may degrade with exposure to light. There are dark-colored 15ml bottles that minimize this exposure.
  • Paper, tape, and a writing utensil to label the bottle


Certain psychoactive substances (particularly benzodiazepines) are practically insoluble in water but will dissolve at various concentrations in other easy-to-acquire solvents, such as alcohol, propylene glycol, or glycerine. However, even when added to the correct solvent type the solution may need a mild hot water bath or agitation (shaking or stirring) to get a homogeneous solution. A hot water bath involves placing the substance container into a bigger container with hot water inside of it. This heats up the solution in the container so that it may dissolve better. The substance may precipitate out of the solution and the process of light heat/agitation may need to repeated again. Always check your solutions for precipitates before using it.

The first important consideration is the maximum concentration at which your chosen solvent will dissolve your product. A value can usually be found with minimal effort on the internet, using a search term like "<material> <solvent> solubility".

Alcohol, in particular, is mixable with most solvents; Just a few drops is usually enough to increase the maximum concentration dramatically, even when using water as the major component.

Adding a small amount of acid (lemon juice, vinegar, etc) to certain solutions can also increase the solute's solubility in the solvent.


For best accuracy, an oral syringe ought to be used to measure the calculated volume of liquid. You can use other measuring tools, like a syringe with a needle, graduated cylinder, eyedropper, measuring pipette, or measuring cups.
If one is using an insulin syringe, then 1cc = 1mL.

For effective dosing, a 1ml syringe with 0.1ml graduations might be used with solutions at a concentration of 10mg/1ml; this supplies 1mg/0.1ml graduation. It may be better to use a lower concentration if your usual dose is below 1mg.


It's vital to weigh the quantity of powder that you want to volumetrically dose with a milligram scale first. Even when the burden is on the bag don't assume that the vendor has given you a certain amount of a material; it isn't uncommon for vendors to give more product than is labeled. If one believes they received 500mg but received 1000mg, then the liquid solution would be two times as strong as anticipated.

Emptying a tote of a material into a container with solvent might leave modest amounts inside the tote. To account for this, begin by weighing your bag with the material inside and note the reading on the scale, move the contents into your solution, then weigh the bag again. The distinction between these weights is the sum of material you've placed in the solution. As an example, if your first fat is 2000mg, and after moving the material the weight of the tote is 750mg, you've moved 1250mg of material.

To achieve a concentration of 10mg/1ml, measure the burden of material in mg, then divide the value by 10. So for 1000mg material, 100ml of solvent would be required. It's safest to use the lowest concentration possible, ideally 1mg/1mL or less for substances active in the 1mg range.


After weighing the material, calculating the concentration, and measuring the required volume of lube, then add the liquid to a container, then cautiously mix in the compound. Seal tightly, then mix thoroughly by shaking the container vigorously.

To aid in dissolution, the container can be placed to heat it up. Following a while, the solvent will probably become less viscous and might be mixed extensively. Be vigilant of the sum of heat used in the warm water tub because water may break down some chemical compounds.

Some compounds need the aid of acid to dissolve in water. Weak acids such as white vinegar or citric acid are legitimate options, but meals grade acetic acid (vinegar) will be the most sterile way of adding acid into the solution.


  • Avoid exposure to heat or direct sun
  • Label the container with contents and concentration
  • Keep in a safe location
  • Periodically check the solution for homogeneity; there should be no particulate matter precipitating out on the bottom of the bottle. The solution needs to be mixed and homogeneous.

Get started with our starter-kit

If you want to make your own liquid solution, this kit contains everything you need to create 1 liter of PG liquid solution from powder.


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